Rac GTPase-activating protein 1 (RACGAP1)
Homo sapiens — UniProt Q9H0H5
Data last refreshed: (UniProt release unknown)
Key facts
Rac GTPase-activating protein 1 (RACGAP1) is a protein from Homo sapiens identified by UniProt accession Q9H0H5, 632 residues long. MolForge cross-references it against 0 known binders and 117 disease associations.
- UniProt accession: Q9H0H5; gene symbol RACGAP1.
- Organism: Homo sapiens.
- Length: 632 amino acids.
- Top disease associations (Open Targets): Anemia, congenital dyserythropoietic, type IIIb, autosomal recessive, Congenital dyserythropoietic anemia type III and glioblastoma multiforme.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rac GTPase-activating protein 1 |
|---|---|
| UniProt accession | Q9H0H5 |
| Gene | RACGAP1 |
| Organism | Homo sapiens |
| Length | 632 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (117)
Diseases linked to this target (Open Targets).
- Anemia, congenital dyserythropoietic, type IIIb, autosomal recessive · score 0.51
- Congenital dyserythropoietic anemia type III · score 0.37
- glioblastoma multiforme · score 0.15
- hepatocellular carcinoma · score 0.11
- neoplasm · score 0.10
- calf circumference measurement · score 0.08
- lung adenocarcinoma · score 0.08
- cancer · score 0.08
- esophageal squamous cell carcinoma · score 0.08
- urinary bladder carcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0H5-F1 | alphafold | PREDICTED | 70.17 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0H5.
Amino-acid sequence (632 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RACGAP1?
The strongest Open Targets associations for RACGAP1 are Anemia, congenital dyserythropoietic, type IIIb, autosomal recessive, Congenital dyserythropoietic anemia type III, glioblastoma multiforme, hepatocellular carcinoma and neoplasm.
How long is the RACGAP1 protein?
The Homo sapiens RACGAP1 protein (UniProt Q9H0H5) is 632 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0H5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0H5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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