Transketolase-like protein 2 (TKTL2)
Homo sapiens — UniProt Q9H0I9
Data last refreshed: (UniProt release unknown)
Key facts
Transketolase-like protein 2 (TKTL2) is a protein from Homo sapiens identified by UniProt accession Q9H0I9, 626 residues long. MolForge cross-references it against 0 known binders and 25 disease associations.
- UniProt accession: Q9H0I9; gene symbol TKTL2.
- Organism: Homo sapiens.
- Length: 626 amino acids.
- Top disease associations (Open Targets): fat body mass, multiple sclerosis and body mass index.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transketolase-like protein 2 |
|---|---|
| UniProt accession | Q9H0I9 |
| Gene | TKTL2 |
| Organism | Homo sapiens |
| Length | 626 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (25)
Diseases linked to this target (Open Targets).
- fat body mass · score 0.10
- multiple sclerosis · score 0.05
- body mass index · score 0.03
- hepatocellular carcinoma · score 0.02
- urate measurement · score 0.02
- bone density · score 0.02
- adolescent idiopathic scoliosis · score 0.02
- Abnormal sperm morphology · score 0.01
- breast cancer · score 0.01
- carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0I9-F1 | alphafold | PREDICTED | 96.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0I9.
Amino-acid sequence (626 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TKTL2?
The strongest Open Targets associations for TKTL2 are fat body mass, multiple sclerosis, body mass index, hepatocellular carcinoma and urate measurement.
How long is the TKTL2 protein?
The Homo sapiens TKTL2 protein (UniProt Q9H0I9) is 626 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0I9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0I9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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