Glutamine-rich protein 2 (QRICH2)

Homo sapiens — UniProt Q9H0J4

Gene: QRICH2Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Glutamine-rich protein 2 (QRICH2) is a protein from Homo sapiens identified by UniProt accession Q9H0J4, 1663 residues long. MolForge cross-references it against 0 known binders and 123 disease associations.

UniProt accession: Q9H0J4; gene symbol QRICH2.
Organism: Homo sapiens.
Length: 1663 amino acids.
Top disease associations (Open Targets): azoospermia, urate measurement and triglyceride measurement.
3D structure: AlphaFold model available.

Target properties

Protein name	Glutamine-rich protein 2
UniProt accession	Q9H0J4
Gene	QRICH2
Organism	Homo sapiens
Length	1663 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (123)

Diseases linked to this target (Open Targets).

azoospermia · score 0.66
urate measurement · score 0.32
triglyceride measurement · score 0.27
mean reticulocyte volume · score 0.25
reticulocyte measurement · score 0.25
reticulocyte count · score 0.24
uric acid measurement · score 0.16
BMI-adjusted waist-hip ratio · score 0.13
high density lipoprotein cholesterol measurement · score 0.13
male infertility with teratozoospermia due to single gene mutation · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9H0J4-F1	alphafold	PREDICTED	44.56	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0J4.

Amino-acid sequence (1663 residues)

MKDAAEELSF ARVLLQRVDE LEKLFKDREQ FLELVSRKLS LVPGAEEVTM VTWEELEQAI TDGWRASQAG SETLMGFSKH GGFTSLTSPE GTLSGDSTKQ PSIEQALDSA SGLGPDRTAS GSGGTAHPSD GVSSREQSKV PSGTGRQQQP RARDEAGVPR LHQSSTFQFK SDSDRHRSRE KLTSTQPRRN ARPGPVQQDL PLARDQPSSV PASQSQVHLR PDRRGLEPTG MNQPGLVPAS TYPHGVVPLS MGQLGVPPPE MDDRELIPFV VDEQRMLPPS VPGRDQQGLE LPSTDQHGLV SVSAYQHGMT FPGTDQRSME PLGMDQRGCV ISGMGQQGLV PPGIDQQGLT LPVVDQHGLV LPFTDQHGLV SPGLMPISAD QQGFVQPSLE ATGFIQPGTE QHDLIQSGRF QRALVQRGAY QPGLVQPGAD QRGLVRPGMD QSGLAQPGAD QRGLVWPGMD QSGLAQPGRD QHGLIQPGTG QHDLVQSGTG QGVLVQPGVD QPGMVQPGRF QRALVQPGAY QPGLVQPGAD QIDVVQPGAD QHGLVQSGAD QSDLAQPGAV QHGLVQPGVD QRGLAQPRAD HQRGLVPPGA DQRGLVQPGA DQHGLVQPGV DQHGLAQPGE VQRSLVQPGI VQRGLVQPGA VQRGLVQPGA VQRGLVQPGV DQRGLVQPGA VQRGLVQPGA VQHGLVQPGA DQRGLVQPGV DQRGLVQPGV DQRGLVQPGM DQRGLIQPGA DQPGLVQPGA GQLGMVQPGI GQQGMVQPQA DPHGLVQPGA YPLGLVQPGA YLHDLSQSGT YPRGLVQPGM DQYGLRQPGA YQPGLIAPGT KLRGSSTFQA DSTGFISVRP YQHGMVPPGR EQYGQVSPLL ASQGLASPGI DRRSLVPPET YQQGLMHPGT DQHSPIPLST GLGSTHPDQQ HVASPGPGEH DQVYPDAAQH GHAFSLFDSH DSMYPGYRGP GYLSADQHGQ EGLDPNRTRA SDRHGIPAQK APGQDVTLFR SPDSVDRVLS EGSEVSSEVL SERRNSLRRM SSSFPTAVET FHLMGELSSL YVGLKESMKD LDEEQAGQTD LEKIQFLLAQ MVKRTIPPEL QEQLKTVKTL AKEVWQEKAK VERLQRILEG EGNQEAGKEL KAGELRLQLG VLRVTVADIE KELAELRESQ DRGKAAMENS VSEASLYLQD QLDKLRMIIE SMLTSSSTLL SMSMAPHKAH TLAPGQIDPE ATCPACSLDV SHQVSTLVRR YEQLQDMVNS LAVSRPSKKA KLQRQDEELL GRVQSAILQV QGDCEKLNIT TSNLIEDHRQ KQKDIAMLYQ GLEKLEKEKA NREHLEMEID VKADKSALAT KVSRVQFDAT TEQLNHMMQE LVAKMSGQEQ DWQKMLDRLL TEMDNKLDRL ELDPVKQLLE DRWKSLRQQL RERPPLYQAD EAAAMRRQLL AHFHCLSCDR PLETPVTGHA IPVTPAGPGL PGHHSIRPYT VFELEQVRQH SRNLKLGSAF PRGDLAQMEQ SVGRLRSMHS KMLMNIEKVQ IHFGGSTKAS SQIIRELLHA QCLGSPCYKR VTDMADYTYS TVPRRCGGSH TLTYPYHRSR PQHLPRGLYP TEEIQIAMKH DEVDILGLDG HIYKGRMDTR LPGILRKDSS GTSKRKSQQP RPHVHRPPSL SSNGQLPSRP QSAQISAGNT SER

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with QRICH2?

The strongest Open Targets associations for QRICH2 are azoospermia, urate measurement, triglyceride measurement, mean reticulocyte volume and reticulocyte measurement.

How long is the QRICH2 protein?

The Homo sapiens QRICH2 protein (UniProt Q9H0J4) is 1663 amino acids long.

Browse: Targets: Q · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q9H0J4 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q9H0J4 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.