Protein mono-ADP-ribosyltransferase PARP12 (PARP12)
Homo sapiens — UniProt Q9H0J9
Data last refreshed: (UniProt release unknown)
Key facts
Protein mono-ADP-ribosyltransferase PARP12 (PARP12) is a protein from Homo sapiens identified by UniProt accession Q9H0J9, 701 residues long. MolForge cross-references it against 3 known binders and 67 disease associations.
- UniProt accession: Q9H0J9; gene symbol PARP12.
- Organism: Homo sapiens.
- Length: 701 amino acids.
- Approved drugs acting on it (DrugCentral): Rucaparib.
- Top disease associations (Open Targets): neurodegenerative disease, body height and coronary artery disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein mono-ADP-ribosyltransferase PARP12 |
|---|---|
| UniProt accession | Q9H0J9 |
| Gene | PARP12 |
| Organism | Homo sapiens |
| Length | 701 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (67)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- body height · score 0.43
- coronary artery disease · score 0.40
- lean body mass · score 0.39
- appendicular lean mass · score 0.38
- leukocyte count · score 0.36
- myeloid white cell count · score 0.36
- monocyte count · score 0.35
- eosinophil count · score 0.34
- vital capacity · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0J9-F1 | alphafold | PREDICTED | 83.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0J9.
Amino-acid sequence (701 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target PARP12?
DrugCentral lists 1 approved drug whose mechanism of action is PARP12: Rucaparib.
Which diseases are associated with PARP12?
The strongest Open Targets associations for PARP12 are neurodegenerative disease, body height, coronary artery disease, lean body mass and appendicular lean mass.
How long is the PARP12 protein?
The Homo sapiens PARP12 protein (UniProt Q9H0J9) is 701 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0J9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0J9 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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