Serine/threonine-protein kinase SIK2 (SIK2)
Homo sapiens — UniProt Q9H0K1
Data last refreshed: (UniProt release unknown)
Key facts
Serine/threonine-protein kinase SIK2 (SIK2) is a protein from Homo sapiens identified by UniProt accession Q9H0K1, 926 residues long. MolForge cross-references it against 17 known binders and 150 disease associations.
- UniProt accession: Q9H0K1; gene symbol SIK2.
- Organism: Homo sapiens.
- Length: 926 amino acids.
- Top disease associations (Open Targets): neuroinflammatory disorder, neurodegenerative disease and self reported educational attainment.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine/threonine-protein kinase SIK2 |
|---|---|
| UniProt accession | Q9H0K1 |
| Gene | SIK2 |
| Organism | Homo sapiens |
| Length | 926 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (150)
Diseases linked to this target (Open Targets).
- neuroinflammatory disorder · score 0.37
- neurodegenerative disease · score 0.30
- self reported educational attainment · score 0.24
- asthma · score 0.23
- mathematical ability · score 0.21
- Agents acting on the renin-angiotensin system use measurement · score 0.20
- eosinophil count · score 0.19
- diet measurement · score 0.19
- allergic disease · score 0.19
- Eczematoid dermatitis · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0K1-F1 | alphafold | PREDICTED | 57.80 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0K1.
Amino-acid sequence (926 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SIK2?
The strongest Open Targets associations for SIK2 are neuroinflammatory disorder, neurodegenerative disease, self reported educational attainment, asthma and mathematical ability.
How long is the SIK2 protein?
The Homo sapiens SIK2 protein (UniProt Q9H0K1) is 926 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0K1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0K1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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