Pseudouridylate synthase PUS7L (PUS7L)
Homo sapiens — UniProt Q9H0K6
Data last refreshed: (UniProt release unknown)
Key facts
Pseudouridylate synthase PUS7L (PUS7L) is a protein from Homo sapiens identified by UniProt accession Q9H0K6, 701 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.
- UniProt accession: Q9H0K6; gene symbol PUS7L.
- Organism: Homo sapiens.
- Length: 701 amino acids.
- Top disease associations (Open Targets): cytokine measurement, response to vaccine and Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pseudouridylate synthase PUS7L |
|---|---|
| UniProt accession | Q9H0K6 |
| Gene | PUS7L |
| Organism | Homo sapiens |
| Length | 701 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (16)
Diseases linked to this target (Open Targets).
- cytokine measurement · score 0.29
- response to vaccine · score 0.29
- Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency · score 0.12
- genetic disorder · score 0.12
- immunodeficiency 67 · score 0.12
- Ataxia-telangiectasia · score 0.04
- metabolite measurement · score 0.03
- hepatocellular carcinoma · score 0.01
- glioblastoma multiforme · score 0.01
- prostate adenocarcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0K6-F1 | alphafold | PREDICTED | 76.60 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0K6.
Amino-acid sequence (701 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PUS7L?
The strongest Open Targets associations for PUS7L are cytokine measurement, response to vaccine, Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency, genetic disorder and immunodeficiency 67.
How long is the PUS7L protein?
The Homo sapiens PUS7L protein (UniProt Q9H0K6) is 701 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0K6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0K6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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