NEDD4-like E3 ubiquitin-protein ligase WWP1 (WWP1)
Homo sapiens — UniProt Q9H0M0
Data last refreshed: (UniProt release unknown)
Key facts
NEDD4-like E3 ubiquitin-protein ligase WWP1 (WWP1) is a protein from Homo sapiens identified by UniProt accession Q9H0M0, 922 residues long. MolForge cross-references it against 0 known binders and 165 disease associations.
- UniProt accession: Q9H0M0; gene symbol WWP1.
- Organism: Homo sapiens.
- Length: 922 amino acids.
- Top disease associations (Open Targets): age at menarche, creatinine measurement and urate measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | NEDD4-like E3 ubiquitin-protein ligase WWP1 |
|---|---|
| UniProt accession | Q9H0M0 |
| Gene | WWP1 |
| Organism | Homo sapiens |
| Length | 922 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (165)
Diseases linked to this target (Open Targets).
- age at menarche · score 0.30
- creatinine measurement · score 0.30
- urate measurement · score 0.27
- HbA1c measurement · score 0.24
- glomerular filtration rate · score 0.23
- breast adenocarcinoma · score 0.23
- head and neck squamous cell carcinoma · score 0.22
- lung adenocarcinoma · score 0.21
- body fat percentage · score 0.20
- body mass index · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0M0-F1 | alphafold | PREDICTED | 75.41 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0M0.
Amino-acid sequence (922 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with WWP1?
The strongest Open Targets associations for WWP1 are age at menarche, creatinine measurement, urate measurement, HbA1c measurement and glomerular filtration rate.
How long is the WWP1 protein?
The Homo sapiens WWP1 protein (UniProt Q9H0M0) is 922 amino acids long.
Browse: Targets: W · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0M0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0M0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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