CYFIP-related Rac1 interactor A (CYRIA)
Homo sapiens — UniProt Q9H0Q0
Data last refreshed: (UniProt release unknown)
Key facts
CYFIP-related Rac1 interactor A (CYRIA) is a protein from Homo sapiens identified by UniProt accession Q9H0Q0, 323 residues long. MolForge cross-references it against 0 known binders and 100 disease associations.
- UniProt accession: Q9H0Q0; gene symbol CYRIA.
- Organism: Homo sapiens.
- Length: 323 amino acids.
- Top disease associations (Open Targets): cleft lip, Orofacial cleft and Cleft palate.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | CYFIP-related Rac1 interactor A |
|---|---|
| UniProt accession | Q9H0Q0 |
| Gene | CYRIA |
| Organism | Homo sapiens |
| Length | 323 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (100)
Diseases linked to this target (Open Targets).
- cleft lip · score 0.42
- Orofacial cleft · score 0.41
- Cleft palate · score 0.39
- monocyte count · score 0.35
- myeloid white cell count · score 0.35
- mean platelet volume · score 0.33
- platelet count · score 0.32
- breast milk measurement · score 0.31
- glomerular filtration rate · score 0.31
- adolescent idiopathic scoliosis · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0Q0-F1 | alphafold | PREDICTED | 92.77 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0Q0.
Amino-acid sequence (323 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CYRIA?
The strongest Open Targets associations for CYRIA are cleft lip, Orofacial cleft, Cleft palate, monocyte count and myeloid white cell count.
How long is the CYRIA protein?
The Homo sapiens CYRIA protein (UniProt Q9H0Q0) is 323 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0Q0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0Q0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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