Transmembrane protein 222 (TMEM222)
Homo sapiens — UniProt Q9H0R3
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 222 (TMEM222) is a protein from Homo sapiens identified by UniProt accession Q9H0R3, 208 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.
- UniProt accession: Q9H0R3; gene symbol TMEM222.
- Organism: Homo sapiens.
- Length: 208 amino acids.
- Top disease associations (Open Targets): neurodevelopmental disorder with motor and speech delay and behavioral abnormalities, Intellectual disability and Atypical behavior.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 222 |
|---|---|
| UniProt accession | Q9H0R3 |
| Gene | TMEM222 |
| Organism | Homo sapiens |
| Length | 208 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (14)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with motor and speech delay and behavioral abnormalities · score 0.65
- Intellectual disability · score 0.46
- Atypical behavior · score 0.46
- Delayed speech and language development · score 0.46
- Seizure · score 0.46
- Microcephaly · score 0.46
- Motor delay · score 0.46
- Generalized hypotonia · score 0.46
- Broad-based gait · score 0.46
- microcephaly · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0R3-F1 | alphafold | PREDICTED | 84.80 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0R3.
Amino-acid sequence (208 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM222?
The strongest Open Targets associations for TMEM222 are neurodevelopmental disorder with motor and speech delay and behavioral abnormalities, Intellectual disability, Atypical behavior, Delayed speech and language development and Seizure.
How long is the TMEM222 protein?
The Homo sapiens TMEM222 protein (UniProt Q9H0R3) is 208 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0R3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0R3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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