Haloacid dehalogenase-like hydrolase domain-containing protein 2 (HDHD2)
Homo sapiens — UniProt Q9H0R4
Data last refreshed: (UniProt release unknown)
Key facts
Haloacid dehalogenase-like hydrolase domain-containing protein 2 (HDHD2) is a protein from Homo sapiens identified by UniProt accession Q9H0R4, 259 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.
- UniProt accession: Q9H0R4; gene symbol HDHD2.
- Organism: Homo sapiens.
- Length: 259 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, blood protein measurement and age at menarche.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Haloacid dehalogenase-like hydrolase domain-containing protein 2 |
|---|---|
| UniProt accession | Q9H0R4 |
| Gene | HDHD2 |
| Organism | Homo sapiens |
| Length | 259 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (14)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- blood protein measurement · score 0.20
- age at menarche · score 0.05
- testosterone measurement · score 0.04
- body mass index · score 0.04
- P-selectin glycoprotein ligand 1 measurement · score 0.03
- BMI-adjusted waist circumference · score 0.03
- chronotype measurement · score 0.03
- BMI-adjusted hip circumference · score 0.03
- self reported educational attainment · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0R4-F1 | alphafold | PREDICTED | 95.23 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0R4.
Amino-acid sequence (259 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HDHD2?
The strongest Open Targets associations for HDHD2 are neurodegenerative disease, blood protein measurement, age at menarche, testosterone measurement and body mass index.
How long is the HDHD2 protein?
The Homo sapiens HDHD2 protein (UniProt Q9H0R4) is 259 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0R4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0R4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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