Guanylate-binding protein 3 (GBP3)
Homo sapiens — UniProt Q9H0R5
Data last refreshed: (UniProt release unknown)
Key facts
Guanylate-binding protein 3 (GBP3) is a protein from Homo sapiens identified by UniProt accession Q9H0R5, 595 residues long. MolForge cross-references it against 0 known binders and 123 disease associations.
- UniProt accession: Q9H0R5; gene symbol GBP3.
- Organism: Homo sapiens.
- Length: 595 amino acids.
- Top disease associations (Open Targets): isolated agammaglobulinemia, Immunodeficiency due to a late component of complements deficiency and recurrent infections associated with rare immunoglobulin isotypes deficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Guanylate-binding protein 3 |
|---|---|
| UniProt accession | Q9H0R5 |
| Gene | GBP3 |
| Organism | Homo sapiens |
| Length | 595 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (123)
Diseases linked to this target (Open Targets).
- isolated agammaglobulinemia · score 0.07
- Immunodeficiency due to a late component of complements deficiency · score 0.06
- recurrent infections associated with rare immunoglobulin isotypes deficiency · score 0.06
- selective IgA deficiency disease · score 0.05
- Immunodeficiency by defective expression of HLA class 2 · score 0.05
- mannose-binding lectin deficiency · score 0.05
- immunodeficiency 35 · score 0.05
- hyper-IgM syndrome type 2 · score 0.05
- X-linked agammaglobulinemia · score 0.05
- gamma chain deficiency · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0R5-F1 | alphafold | PREDICTED | 88.38 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0R5.
Amino-acid sequence (595 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GBP3?
The strongest Open Targets associations for GBP3 are isolated agammaglobulinemia, Immunodeficiency due to a late component of complements deficiency, recurrent infections associated with rare immunoglobulin isotypes deficiency, selective IgA deficiency disease and Immunodeficiency by defective expression of HLA class 2.
How long is the GBP3 protein?
The Homo sapiens GBP3 protein (UniProt Q9H0R5) is 595 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0R5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0R5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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