Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1)
Homo sapiens — UniProt Q9H0R8
Data last refreshed: (UniProt release unknown)
Key facts
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) is a protein from Homo sapiens identified by UniProt accession Q9H0R8, 117 residues long. MolForge cross-references it against 0 known binders and 122 disease associations.
- UniProt accession: Q9H0R8; gene symbol GABARAPL1.
- Organism: Homo sapiens.
- Length: 117 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, neoplasm and pancreatic adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Gamma-aminobutyric acid receptor-associated protein-like 1 |
|---|---|
| UniProt accession | Q9H0R8 |
| Gene | GABARAPL1 |
| Organism | Homo sapiens |
| Length | 117 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (122)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.23
- neoplasm · score 0.11
- pancreatic adenocarcinoma · score 0.10
- cryopyrin-associated periodic syndrome · score 0.09
- hepatocellular carcinoma · score 0.08
- acute myocardial infarction · score 0.08
- breast cancer · score 0.08
- triple-negative breast cancer · score 0.08
- cancer · score 0.05
- gonorrhea · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0R8-F1 | alphafold | PREDICTED | 94.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0R8.
Amino-acid sequence (117 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GABARAPL1?
The strongest Open Targets associations for GABARAPL1 are neurodegenerative disease, neoplasm, pancreatic adenocarcinoma, cryopyrin-associated periodic syndrome and hepatocellular carcinoma.
How long is the GABARAPL1 protein?
The Homo sapiens GABARAPL1 protein (UniProt Q9H0R8) is 117 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0R8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0R8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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