Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1 (MAGT1)
Homo sapiens — UniProt Q9H0U3
Data last refreshed: (UniProt release unknown)
Key facts
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1 (MAGT1) is a protein from Homo sapiens identified by UniProt accession Q9H0U3, 335 residues long. MolForge cross-references it against 0 known binders and 170 disease associations.
- UniProt accession: Q9H0U3; gene symbol MAGT1.
- Organism: Homo sapiens.
- Length: 335 amino acids.
- Top disease associations (Open Targets): X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia, congenital disorder of glycosylation type I and combined immunodeficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1 |
|---|---|
| UniProt accession | Q9H0U3 |
| Gene | MAGT1 |
| Organism | Homo sapiens |
| Length | 335 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (170)
Diseases linked to this target (Open Targets).
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia · score 0.76
- congenital disorder of glycosylation type I · score 0.67
- combined immunodeficiency · score 0.46
- Combined immunodeficiency · score 0.46
- congenital disorder of glycosylation · score 0.43
- COVID-19 · score 0.37
- genetic disorder · score 0.19
- Graves disease · score 0.14
- common variable immunodeficiency · score 0.06
- pachyonychia congenita · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0U3-F1 | alphafold | PREDICTED | 85.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0U3.
Amino-acid sequence (335 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MAGT1?
The strongest Open Targets associations for MAGT1 are X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia, congenital disorder of glycosylation type I, combined immunodeficiency, Combined immunodeficiency and congenital disorder of glycosylation.
How long is the MAGT1 protein?
The Homo sapiens MAGT1 protein (UniProt Q9H0U3) is 335 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0U3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0U3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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