Large ribosomal subunit protein uL18m (MRPL18)
Homo sapiens — UniProt Q9H0U6
Data last refreshed: (UniProt release unknown)
Key facts
Large ribosomal subunit protein uL18m (MRPL18) is a protein from Homo sapiens identified by UniProt accession Q9H0U6, 180 residues long. MolForge cross-references it against 0 known binders and 73 disease associations.
- UniProt accession: Q9H0U6; gene symbol MRPL18.
- Organism: Homo sapiens.
- Length: 180 amino acids.
- Top disease associations (Open Targets): lipoprotein A measurement, neurodegenerative disease and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Large ribosomal subunit protein uL18m |
|---|---|
| UniProt accession | Q9H0U6 |
| Gene | MRPL18 |
| Organism | Homo sapiens |
| Length | 180 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (73)
Diseases linked to this target (Open Targets).
- lipoprotein A measurement · score 0.50
- neurodegenerative disease · score 0.20
- breast adenocarcinoma · score 0.18
- early-onset non-syndromic cataract · score 0.07
- Cataract-microcornea syndrome · score 0.06
- Total congenital cataract · score 0.06
- isolated ectopia lentis · score 0.06
- Anterior polar cataract · score 0.06
- Familial ocular anterior segment mesenchymal dysgenesis · score 0.05
- Posterior polar cataract · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0U6-F1 | alphafold | PREDICTED | 86.60 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0U6.
Amino-acid sequence (180 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MRPL18?
The strongest Open Targets associations for MRPL18 are lipoprotein A measurement, neurodegenerative disease, breast adenocarcinoma, early-onset non-syndromic cataract and Cataract-microcornea syndrome.
How long is the MRPL18 protein?
The Homo sapiens MRPL18 protein (UniProt Q9H0U6) is 180 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0U6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0U6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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