Testis-specific Y-encoded-like protein 1 (TSPYL1)
Homo sapiens — UniProt Q9H0U9
Data last refreshed: (UniProt release unknown)
Key facts
Testis-specific Y-encoded-like protein 1 (TSPYL1) is a protein from Homo sapiens identified by UniProt accession Q9H0U9, 437 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.
- UniProt accession: Q9H0U9; gene symbol TSPYL1.
- Organism: Homo sapiens.
- Length: 437 amino acids.
- Top disease associations (Open Targets): sudden infant death-dysgenesis of the testes syndrome, Sudden infant death - dysgenesis of the testes and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Testis-specific Y-encoded-like protein 1 |
|---|---|
| UniProt accession | Q9H0U9 |
| Gene | TSPYL1 |
| Organism | Homo sapiens |
| Length | 437 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (50)
Diseases linked to this target (Open Targets).
- sudden infant death-dysgenesis of the testes syndrome · score 0.69
- Sudden infant death - dysgenesis of the testes · score 0.66
- neurodegenerative disease · score 0.47
- genetic disorder · score 0.19
- FEV/FVC ratio · score 0.11
- Myopia · score 0.10
- major depressive disorder · score 0.05
- uncombable hair syndrome · score 0.04
- Griscelli syndrome type 3 · score 0.04
- Griscelli disease · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0U9-F1 | alphafold | PREDICTED | 60.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0U9.
Amino-acid sequence (437 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TSPYL1?
The strongest Open Targets associations for TSPYL1 are sudden infant death-dysgenesis of the testes syndrome, Sudden infant death - dysgenesis of the testes, neurodegenerative disease, genetic disorder and FEV/FVC ratio.
How long is the TSPYL1 protein?
The Homo sapiens TSPYL1 protein (UniProt Q9H0U9) is 437 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0U9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0U9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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