Transmembrane protein 168 (TMEM168)
Homo sapiens — UniProt Q9H0V1
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 168 (TMEM168) is a protein from Homo sapiens identified by UniProt accession Q9H0V1, 697 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.
- UniProt accession: Q9H0V1; gene symbol TMEM168.
- Organism: Homo sapiens.
- Length: 697 amino acids.
- Top disease associations (Open Targets): glioblastoma multiforme, anxiety and chronic kidney disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 168 |
|---|---|
| UniProt accession | Q9H0V1 |
| Gene | TMEM168 |
| Organism | Homo sapiens |
| Length | 697 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (10)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.07
- anxiety · score 0.03
- chronic kidney disease · score 0.01
- glioblastoma · score 0.01
- Brugada syndrome · score 0.01
- schizophrenia · score 0.00
- methamphetamine dependence · score 0.00
- type 1 diabetes mellitus · score 0.00
- hepatocellular carcinoma · score 0.00
- pancreatic ductal adenocarcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0V1-F1 | alphafold | PREDICTED | 83.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0V1.
Amino-acid sequence (697 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM168?
The strongest Open Targets associations for TMEM168 are glioblastoma multiforme, anxiety, chronic kidney disease, glioblastoma and Brugada syndrome.
How long is the TMEM168 protein?
The Homo sapiens TMEM168 protein (UniProt Q9H0V1) is 697 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0V1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0V1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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