Coiled-coil domain-containing protein 8 (CCDC8)
Homo sapiens — UniProt Q9H0W5
Data last refreshed: (UniProt release unknown)
Key facts
Coiled-coil domain-containing protein 8 (CCDC8) is a protein from Homo sapiens identified by UniProt accession Q9H0W5, 538 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.
- UniProt accession: Q9H0W5; gene symbol CCDC8.
- Organism: Homo sapiens.
- Length: 538 amino acids.
- Top disease associations (Open Targets): 3M syndrome, body height and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Coiled-coil domain-containing protein 8 |
|---|---|
| UniProt accession | Q9H0W5 |
| Gene | CCDC8 |
| Organism | Homo sapiens |
| Length | 538 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (33)
Diseases linked to this target (Open Targets).
- 3M syndrome · score 0.77
- body height · score 0.30
- genetic disorder · score 0.19
- Immunodeficiency · score 0.12
- total cholesterol measurement · score 0.05
- Oral ulcer · score 0.05
- ulcer disease · score 0.05
- neoplasm · score 0.04
- serum gamma-glutamyl transferase measurement · score 0.03
- age at menopause · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0W5-F1 | alphafold | PREDICTED | 46.39 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0W5.
Amino-acid sequence (538 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CCDC8?
The strongest Open Targets associations for CCDC8 are 3M syndrome, body height, genetic disorder, Immunodeficiency and total cholesterol measurement.
How long is the CCDC8 protein?
The Homo sapiens CCDC8 protein (UniProt Q9H0W5) is 538 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0W5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0W5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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