THAP domain-containing protein 2 (THAP2)
Homo sapiens — UniProt Q9H0W7
Data last refreshed: (UniProt release unknown)
Key facts
THAP domain-containing protein 2 (THAP2) is a protein from Homo sapiens identified by UniProt accession Q9H0W7, 228 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.
- UniProt accession: Q9H0W7; gene symbol THAP2.
- Organism: Homo sapiens.
- Length: 228 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, small intestine cancer and electrocardiography.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | THAP domain-containing protein 2 |
|---|---|
| UniProt accession | Q9H0W7 |
| Gene | THAP2 |
| Organism | Homo sapiens |
| Length | 228 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (16)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.30
- small intestine cancer · score 0.18
- electrocardiography · score 0.16
- Cleft palate · score 0.12
- cleft lip · score 0.12
- adrenal cortex carcinoma · score 0.02
- psoriasis · score 0.01
- Allergy · score 0.01
- tuberculosis · score 0.01
- neoplasm · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0W7-F1 | alphafold | PREDICTED | 75.27 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0W7.
Amino-acid sequence (228 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with THAP2?
The strongest Open Targets associations for THAP2 are neurodegenerative disease, small intestine cancer, electrocardiography, Cleft palate and cleft lip.
How long is the THAP2 protein?
The Homo sapiens THAP2 protein (UniProt Q9H0W7) is 228 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0W7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0W7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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