Nonsense-mediated mRNA decay factor SMG9 (SMG9)
Homo sapiens — UniProt Q9H0W8
Data last refreshed: (UniProt release unknown)
Key facts
Nonsense-mediated mRNA decay factor SMG9 (SMG9) is a protein from Homo sapiens identified by UniProt accession Q9H0W8, 520 residues long. MolForge cross-references it against 0 known binders and 140 disease associations.
- UniProt accession: Q9H0W8; gene symbol SMG9.
- Organism: Homo sapiens.
- Length: 520 amino acids.
- Top disease associations (Open Targets): Autosomal dominant deafness-onychodystrophy syndrome, neurodevelopmental disorder with intention tremor, pyramidal signs, dyspraxia, and ocular anomalies and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nonsense-mediated mRNA decay factor SMG9 |
|---|---|
| UniProt accession | Q9H0W8 |
| Gene | SMG9 |
| Organism | Homo sapiens |
| Length | 520 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (140)
Diseases linked to this target (Open Targets).
- Autosomal dominant deafness-onychodystrophy syndrome · score 0.63
- neurodevelopmental disorder with intention tremor, pyramidal signs, dyspraxia, and ocular anomalies · score 0.45
- genetic disorder · score 0.41
- Global developmental delay · score 0.33
- Brainstem dysplasia · score 0.33
- Neurodevelopmental abnormality · score 0.33
- Abnormal cardiovascular system morphology · score 0.33
- Abnormal facial shape · score 0.33
- autism spectrum disorder · score 0.33
- lymphocyte count · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H0W8-F1 | alphafold | PREDICTED | 70.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H0W8.
Amino-acid sequence (520 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMG9?
The strongest Open Targets associations for SMG9 are Autosomal dominant deafness-onychodystrophy syndrome, neurodevelopmental disorder with intention tremor, pyramidal signs, dyspraxia, and ocular anomalies, genetic disorder, Global developmental delay and Brainstem dysplasia.
How long is the SMG9 protein?
The Homo sapiens SMG9 protein (UniProt Q9H0W8) is 520 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H0W8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H0W8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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