Signal-regulatory protein delta (SIRPD)
Homo sapiens — UniProt Q9H106
Data last refreshed: (UniProt release unknown)
Key facts
Signal-regulatory protein delta (SIRPD) is a protein from Homo sapiens identified by UniProt accession Q9H106, 197 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.
- UniProt accession: Q9H106; gene symbol SIRPD.
- Organism: Homo sapiens.
- Length: 197 amino acids.
- Top disease associations (Open Targets): mean platelet volume, systemic lupus erythematosus and platelet component distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Signal-regulatory protein delta |
|---|---|
| UniProt accession | Q9H106 |
| Gene | SIRPD |
| Organism | Homo sapiens |
| Length | 197 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (36)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.41
- systemic lupus erythematosus · score 0.29
- platelet component distribution width · score 0.24
- schizophrenia · score 0.23
- attention deficit hyperactivity disorder · score 0.23
- platelet crit · score 0.18
- monocyte count · score 0.15
- blood protein measurement · score 0.13
- reticulocyte count · score 0.13
- monocyte percentage of leukocytes · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H106-F1 | alphafold | PREDICTED | 79.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H106.
Amino-acid sequence (197 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SIRPD?
The strongest Open Targets associations for SIRPD are mean platelet volume, systemic lupus erythematosus, platelet component distribution width, schizophrenia and attention deficit hyperactivity disorder.
How long is the SIRPD protein?
The Homo sapiens SIRPD protein (UniProt Q9H106) is 197 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H106 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H106 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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