GDNF-inducible zinc finger protein 1 (GZF1)
Homo sapiens — UniProt Q9H116
Data last refreshed: (UniProt release unknown)
Key facts
GDNF-inducible zinc finger protein 1 (GZF1) is a protein from Homo sapiens identified by UniProt accession Q9H116, 711 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.
- UniProt accession: Q9H116; gene symbol GZF1.
- Organism: Homo sapiens.
- Length: 711 amino acids.
- Top disease associations (Open Targets): joint laxity, short stature, and myopia, Larsen syndrome and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | GDNF-inducible zinc finger protein 1 |
|---|---|
| UniProt accession | Q9H116 |
| Gene | GZF1 |
| Organism | Homo sapiens |
| Length | 711 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (88)
Diseases linked to this target (Open Targets).
- joint laxity, short stature, and myopia · score 0.72
- Larsen syndrome · score 0.51
- genetic disorder · score 0.19
- benign neoplasm of adrenal gland · score 0.15
- early-onset non-syndromic cataract · score 0.06
- Cataract-microcornea syndrome · score 0.06
- hemolytic anemia due to glutathione reductase deficiency · score 0.05
- hereditary hyperferritinemia with congenital cataracts · score 0.05
- isolated ectopia lentis · score 0.05
- Familial ocular anterior segment mesenchymal dysgenesis · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H116-F1 | alphafold | PREDICTED | 59.34 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H116.
Amino-acid sequence (711 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GZF1?
The strongest Open Targets associations for GZF1 are joint laxity, short stature, and myopia, Larsen syndrome, genetic disorder, benign neoplasm of adrenal gland and early-onset non-syndromic cataract.
How long is the GZF1 protein?
The Homo sapiens GZF1 protein (UniProt Q9H116) is 711 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H116 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H116 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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