Protocadherin alpha-C1 (PCDHAC1)
Homo sapiens — UniProt Q9H158
Data last refreshed: (UniProt release unknown)
Key facts
Protocadherin alpha-C1 (PCDHAC1) is a protein from Homo sapiens identified by UniProt accession Q9H158, 963 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.
- UniProt accession: Q9H158; gene symbol PCDHAC1.
- Organism: Homo sapiens.
- Length: 963 amino acids.
- Top disease associations (Open Targets): vital capacity, Hirschsprung disease and Abnormality of refraction.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protocadherin alpha-C1 |
|---|---|
| UniProt accession | Q9H158 |
| Gene | PCDHAC1 |
| Organism | Homo sapiens |
| Length | 963 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (13)
Diseases linked to this target (Open Targets).
- vital capacity · score 0.14
- Hirschsprung disease · score 0.11
- Abnormality of refraction · score 0.08
- granulocyte count · score 0.05
- sum of neutrophil and eosinophil counts · score 0.05
- esophageal adenocarcinoma · score 0.04
- myeloid white cell count · score 0.02
- sum of basophil and neutrophil counts · score 0.02
- refractive error · score 0.02
- renal cell carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H158-F1 | alphafold | PREDICTED | 73.05 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H158.
Amino-acid sequence (963 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PCDHAC1?
The strongest Open Targets associations for PCDHAC1 are vital capacity, Hirschsprung disease, Abnormality of refraction, granulocyte count and sum of neutrophil and eosinophil counts.
How long is the PCDHAC1 protein?
The Homo sapiens PCDHAC1 protein (UniProt Q9H158) is 963 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H158 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H158 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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