Inhibitor of growth protein 2 (ING2)
Homo sapiens — UniProt Q9H160
Data last refreshed: (UniProt release unknown)
Key facts
Inhibitor of growth protein 2 (ING2) is a protein from Homo sapiens identified by UniProt accession Q9H160, 280 residues long. MolForge cross-references it against 0 known binders and 147 disease associations.
- UniProt accession: Q9H160; gene symbol ING2.
- Organism: Homo sapiens.
- Length: 280 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, glioblastoma multiforme and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Inhibitor of growth protein 2 |
|---|---|
| UniProt accession | Q9H160 |
| Gene | ING2 |
| Organism | Homo sapiens |
| Length | 280 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (147)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- glioblastoma multiforme · score 0.26
- breast adenocarcinoma · score 0.26
- ovarian cancer · score 0.25
- squamous cell lung carcinoma · score 0.23
- endometrial cancer · score 0.23
- head and neck squamous cell carcinoma · score 0.23
- small cell lung carcinoma · score 0.23
- azoospermia · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H160-F1 | alphafold | PREDICTED | 75.52 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H160.
Amino-acid sequence (280 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ING2?
The strongest Open Targets associations for ING2 are neurodegenerative disease, glioblastoma multiforme, breast adenocarcinoma, ovarian cancer and squamous cell lung carcinoma.
How long is the ING2 protein?
The Homo sapiens ING2 protein (UniProt Q9H160) is 280 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H160 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H160 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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