Homeobox protein aristaless-like 4 (ALX4)
Homo sapiens — UniProt Q9H161
Data last refreshed: (UniProt release unknown)
Key facts
Homeobox protein aristaless-like 4 (ALX4) is a protein from Homo sapiens identified by UniProt accession Q9H161, 411 residues long. MolForge cross-references it against 0 known binders and 298 disease associations.
- UniProt accession: Q9H161; gene symbol ALX4.
- Organism: Homo sapiens.
- Length: 411 amino acids.
- Top disease associations (Open Targets): parietal foramina 2, frontonasal dysplasia with alopecia and genital anomaly and parietal foramina.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Homeobox protein aristaless-like 4 |
|---|---|
| UniProt accession | Q9H161 |
| Gene | ALX4 |
| Organism | Homo sapiens |
| Length | 411 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (298)
Diseases linked to this target (Open Targets).
- parietal foramina 2 · score 0.76
- frontonasal dysplasia with alopecia and genital anomaly · score 0.74
- parietal foramina · score 0.53
- frontonasal dysplasia · score 0.49
- puberty onset measurement · score 0.45
- genetic disorder · score 0.41
- hair color · score 0.40
- brain measurement · score 0.40
- neuroimaging measurement · score 0.40
- cortical surface area measurement · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H161-F1 | alphafold | PREDICTED | 57.59 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H161.
Amino-acid sequence (411 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ALX4?
The strongest Open Targets associations for ALX4 are parietal foramina 2, frontonasal dysplasia with alopecia and genital anomaly, parietal foramina, frontonasal dysplasia and puberty onset measurement.
How long is the ALX4 protein?
The Homo sapiens ALX4 protein (UniProt Q9H161) is 411 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H161 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H161 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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