Z-DNA-binding protein 1 (ZBP1)
Homo sapiens — UniProt Q9H171
Data last refreshed: (UniProt release unknown)
Key facts
Z-DNA-binding protein 1 (ZBP1) is a protein from Homo sapiens identified by UniProt accession Q9H171, 429 residues long. MolForge cross-references it against 0 known binders and 103 disease associations.
- UniProt accession: Q9H171; gene symbol ZBP1.
- Organism: Homo sapiens.
- Length: 429 amino acids.
- Top disease associations (Open Targets): endometrial cancer, cutaneous melanoma and response to tofacitinib.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Z-DNA-binding protein 1 |
|---|---|
| UniProt accession | Q9H171 |
| Gene | ZBP1 |
| Organism | Homo sapiens |
| Length | 429 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (103)
Diseases linked to this target (Open Targets).
- endometrial cancer · score 0.18
- cutaneous melanoma · score 0.18
- response to tofacitinib · score 0.12
- Herpes Zoster · score 0.12
- ovarian cancer · score 0.10
- neoplasm · score 0.09
- Systemic lupus erythematosus · score 0.07
- metabolite measurement · score 0.07
- breast angiosarcoma · score 0.06
- infection · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H171-F1 | alphafold | PREDICTED | 52.89 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H171.
Amino-acid sequence (429 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZBP1?
The strongest Open Targets associations for ZBP1 are endometrial cancer, cutaneous melanoma, response to tofacitinib, Herpes Zoster and ovarian cancer.
How long is the ZBP1 protein?
The Homo sapiens ZBP1 protein (UniProt Q9H171) is 429 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H171 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H171 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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