Nucleotide exchange factor SIL1 (SIL1)
Homo sapiens — UniProt Q9H173
Data last refreshed: (UniProt release unknown)
Key facts
Nucleotide exchange factor SIL1 (SIL1) is a protein from Homo sapiens identified by UniProt accession Q9H173, 461 residues long. MolForge cross-references it against 0 known binders and 167 disease associations.
- UniProt accession: Q9H173; gene symbol SIL1.
- Organism: Homo sapiens.
- Length: 461 amino acids.
- Top disease associations (Open Targets): Marinesco-Sjogren syndrome, Marinesco-Sjögren syndrome and cataract.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nucleotide exchange factor SIL1 |
|---|---|
| UniProt accession | Q9H173 |
| Gene | SIL1 |
| Organism | Homo sapiens |
| Length | 461 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (167)
Diseases linked to this target (Open Targets).
- Marinesco-Sjogren syndrome · score 0.76
- Marinesco-Sjögren syndrome · score 0.74
- cataract · score 0.42
- Generalized hypotonia · score 0.42
- Cerebellar atrophy · score 0.34
- Global developmental delay · score 0.33
- Strabismus · score 0.33
- Constipation · score 0.33
- Urinary incontinence · score 0.33
- ptosis · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H173-F1 | alphafold | PREDICTED | 81.64 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H173.
Amino-acid sequence (461 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SIL1?
The strongest Open Targets associations for SIL1 are Marinesco-Sjogren syndrome, Marinesco-Sjögren syndrome, cataract, Generalized hypotonia and Cerebellar atrophy.
How long is the SIL1 protein?
The Homo sapiens SIL1 protein (UniProt Q9H173) is 461 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H173 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H173 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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