Protein-L-histidine N-pros-methyltransferase (METTL9)
Homo sapiens — UniProt Q9H1A3
Data last refreshed: (UniProt release unknown)
Key facts
Protein-L-histidine N-pros-methyltransferase (METTL9) is a protein from Homo sapiens identified by UniProt accession Q9H1A3, 318 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.
- UniProt accession: Q9H1A3; gene symbol METTL9.
- Organism: Homo sapiens.
- Length: 318 amino acids.
- Top disease associations (Open Targets): unipolar depression, balding measurement and hair shape measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein-L-histidine N-pros-methyltransferase |
|---|---|
| UniProt accession | Q9H1A3 |
| Gene | METTL9 |
| Organism | Homo sapiens |
| Length | 318 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (23)
Diseases linked to this target (Open Targets).
- unipolar depression · score 0.39
- balding measurement · score 0.31
- hair shape measurement · score 0.25
- major depressive disorder · score 0.23
- hepatocellular carcinoma · score 0.08
- neoplasm · score 0.07
- cancer · score 0.03
- drug use measurement · score 0.02
- Sepsis · score 0.02
- bacteriemia · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H1A3-F1 | alphafold | PREDICTED | 83.03 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H1A3.
Amino-acid sequence (318 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with METTL9?
The strongest Open Targets associations for METTL9 are unipolar depression, balding measurement, hair shape measurement, major depressive disorder and hepatocellular carcinoma.
How long is the METTL9 protein?
The Homo sapiens METTL9 protein (UniProt Q9H1A3) is 318 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H1A3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H1A3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.