Anaphase-promoting complex subunit 1 (ANAPC1)
Homo sapiens — UniProt Q9H1A4
Data last refreshed: (UniProt release unknown)
Key facts
Anaphase-promoting complex subunit 1 (ANAPC1) is a protein from Homo sapiens identified by UniProt accession Q9H1A4, 1944 residues long. MolForge cross-references it against 0 known binders and 167 disease associations.
- UniProt accession: Q9H1A4; gene symbol ANAPC1.
- Organism: Homo sapiens.
- Length: 1944 amino acids.
- Top disease associations (Open Targets): Rothmund-Thomson syndrome type 1, heel bone mineral density and erythrocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Anaphase-promoting complex subunit 1 |
|---|---|
| UniProt accession | Q9H1A4 |
| Gene | ANAPC1 |
| Organism | Homo sapiens |
| Length | 1944 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (167)
Diseases linked to this target (Open Targets).
- Rothmund-Thomson syndrome type 1 · score 0.79
- heel bone mineral density · score 0.37
- erythrocyte count · score 0.36
- hemoglobin measurement · score 0.35
- intraocular pressure measurement · score 0.35
- leukocyte count · score 0.34
- lymphocyte count · score 0.31
- FEV/FVC ratio · score 0.31
- corneal endothelial cell measurement · score 0.30
- platelet count · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H1A4-F1 | alphafold | PREDICTED | 77.06 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H1A4.
Amino-acid sequence (1944 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ANAPC1?
The strongest Open Targets associations for ANAPC1 are Rothmund-Thomson syndrome type 1, heel bone mineral density, erythrocyte count, hemoglobin measurement and intraocular pressure measurement.
How long is the ANAPC1 protein?
The Homo sapiens ANAPC1 protein (UniProt Q9H1A4) is 1944 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H1A4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H1A4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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