DNA-directed RNA polymerase II subunit RPB11-b2 (POLR2J3)
Homo sapiens — UniProt Q9H1A7
Data last refreshed: (UniProt release unknown)
Key facts
DNA-directed RNA polymerase II subunit RPB11-b2 (POLR2J3) is a protein from Homo sapiens identified by UniProt accession Q9H1A7, 115 residues long. MolForge cross-references it against 0 known binders and 7 disease associations.
- UniProt accession: Q9H1A7; gene symbol POLR2J3.
- Organism: Homo sapiens.
- Length: 115 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, diabetes mellitus and laryngeal squamous cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DNA-directed RNA polymerase II subunit RPB11-b2 |
|---|---|
| UniProt accession | Q9H1A7 |
| Gene | POLR2J3 |
| Organism | Homo sapiens |
| Length | 115 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (7)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- diabetes mellitus · score 0.06
- laryngeal squamous cell carcinoma · score 0.04
- type 2 diabetes mellitus · score 0.02
- chronotype measurement · score 0.02
- myxosarcoma · score 0.00
- Infertility · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H1A7-F1 | alphafold | PREDICTED | 92.88 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H1A7.
Amino-acid sequence (115 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with POLR2J3?
The strongest Open Targets associations for POLR2J3 are neurodegenerative disease, diabetes mellitus, laryngeal squamous cell carcinoma, type 2 diabetes mellitus and chronotype measurement.
How long is the POLR2J3 protein?
The Homo sapiens POLR2J3 protein (UniProt Q9H1A7) is 115 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H1A7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H1A7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.