Xylosyltransferase 2 (XYLT2)
Homo sapiens — UniProt Q9H1B5
Data last refreshed: (UniProt release unknown)
Key facts
Xylosyltransferase 2 (XYLT2) is a protein from Homo sapiens identified by UniProt accession Q9H1B5, 865 residues long. MolForge cross-references it against 0 known binders and 209 disease associations.
- UniProt accession: Q9H1B5; gene symbol XYLT2.
- Organism: Homo sapiens.
- Length: 865 amino acids.
- Top disease associations (Open Targets): spondylo-ocular syndrome, genetic disorder and autosomal recessive inherited pseudoxanthoma elasticum.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Xylosyltransferase 2 |
|---|---|
| UniProt accession | Q9H1B5 |
| Gene | XYLT2 |
| Organism | Homo sapiens |
| Length | 865 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (209)
Diseases linked to this target (Open Targets).
- spondylo-ocular syndrome · score 0.76
- genetic disorder · score 0.45
- autosomal recessive inherited pseudoxanthoma elasticum · score 0.40
- Pseudoxanthoma elasticum · score 0.37
- osteogenesis imperfecta · score 0.19
- skin pigmentation · score 0.14
- Senior-Boichis syndrome · score 0.06
- renal cysts and diabetes syndrome · score 0.06
- Congenital bile acid synthesis defect type 1 · score 0.06
- nephronophthisis · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H1B5-F1 | alphafold | PREDICTED | 83.85 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H1B5.
Amino-acid sequence (865 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with XYLT2?
The strongest Open Targets associations for XYLT2 are spondylo-ocular syndrome, genetic disorder, autosomal recessive inherited pseudoxanthoma elasticum, Pseudoxanthoma elasticum and osteogenesis imperfecta.
How long is the XYLT2 protein?
The Homo sapiens XYLT2 protein (UniProt Q9H1B5) is 865 amino acids long.
Browse: Targets: X · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H1B5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H1B5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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