Probable E3 ubiquitin-protein ligase IRF2BPL (IRF2BPL)
Homo sapiens — UniProt Q9H1B7
Data last refreshed: (UniProt release unknown)
Key facts
Probable E3 ubiquitin-protein ligase IRF2BPL (IRF2BPL) is a protein from Homo sapiens identified by UniProt accession Q9H1B7, 796 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.
- UniProt accession: Q9H1B7; gene symbol IRF2BPL.
- Organism: Homo sapiens.
- Length: 796 amino acids.
- Top disease associations (Open Targets): neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures, genetic disorder and lean body mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Probable E3 ubiquitin-protein ligase IRF2BPL |
|---|---|
| UniProt accession | Q9H1B7 |
| Gene | IRF2BPL |
| Organism | Homo sapiens |
| Length | 796 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (88)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures · score 0.81
- genetic disorder · score 0.51
- lean body mass · score 0.40
- aspartate aminotransferase measurement · score 0.39
- atrial fibrillation · score 0.39
- smoking status measurement · score 0.38
- serum alanine aminotransferase measurement · score 0.37
- neurodegenerative disease · score 0.37
- autism spectrum disorder · score 0.36
- body mass index · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H1B7-F1 | alphafold | PREDICTED | 60.10 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H1B7.
Amino-acid sequence (796 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IRF2BPL?
The strongest Open Targets associations for IRF2BPL are neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures, genetic disorder, lean body mass, aspartate aminotransferase measurement and atrial fibrillation.
How long is the IRF2BPL protein?
The Homo sapiens IRF2BPL protein (UniProt Q9H1B7) is 796 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H1B7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H1B7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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