Transient receptor potential cation channel subfamily V member 6 (TRPV6)
Homo sapiens — UniProt Q9H1D0
Data last refreshed: (UniProt release unknown)
Key facts
Transient receptor potential cation channel subfamily V member 6 (TRPV6) is a protein from Homo sapiens identified by UniProt accession Q9H1D0, 765 residues long. MolForge cross-references it against 0 known binders and 223 disease associations.
- UniProt accession: Q9H1D0; gene symbol TRPV6.
- Organism: Homo sapiens.
- Length: 765 amino acids.
- Target class: Ion channel.
- Top disease associations (Open Targets): hyperparathyroidism, transient neonatal, neonatal severe primary hyperparathyroidism and alkaline phosphatase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transient receptor potential cation channel subfamily V member 6 |
|---|---|
| UniProt accession | Q9H1D0 |
| Gene | TRPV6 |
| Organism | Homo sapiens |
| Length | 765 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Ion channel (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (223)
Diseases linked to this target (Open Targets).
- hyperparathyroidism, transient neonatal · score 0.76
- neonatal severe primary hyperparathyroidism · score 0.37
- alkaline phosphatase measurement · score 0.28
- hyperparathyroidism · score 0.27
- anxiety measurement · score 0.19
- genetic disorder · score 0.19
- chronic pancreatitis · score 0.19
- glioblastoma multiforme · score 0.18
- breast adenocarcinoma · score 0.16
- hereditary chronic pancreatitis · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H1D0-F1 | alphafold | PREDICTED | 80.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H1D0.
Amino-acid sequence (765 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TRPV6?
The strongest Open Targets associations for TRPV6 are hyperparathyroidism, transient neonatal, neonatal severe primary hyperparathyroidism, alkaline phosphatase measurement, hyperparathyroidism and anxiety measurement.
How long is the TRPV6 protein?
The Homo sapiens TRPV6 protein (UniProt Q9H1D0) is 765 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H1D0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H1D0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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