DNA-directed RNA polymerase III subunit RPC6 (POLR3F)
Homo sapiens — UniProt Q9H1D9
Data last refreshed: (UniProt release unknown)
Key facts
DNA-directed RNA polymerase III subunit RPC6 (POLR3F) is a protein from Homo sapiens identified by UniProt accession Q9H1D9, 316 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.
- UniProt accession: Q9H1D9; gene symbol POLR3F.
- Organism: Homo sapiens.
- Length: 316 amino acids.
- Top disease associations (Open Targets): immunodeficiency 101 (varicella zoster virus-specific), neurofibrillary tangles measurement and body mass index.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DNA-directed RNA polymerase III subunit RPC6 |
|---|---|
| UniProt accession | Q9H1D9 |
| Gene | POLR3F |
| Organism | Homo sapiens |
| Length | 316 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (21)
Diseases linked to this target (Open Targets).
- immunodeficiency 101 (varicella zoster virus-specific) · score 0.45
- neurofibrillary tangles measurement · score 0.03
- body mass index · score 0.03
- age at menarche · score 0.03
- DNA methylation · score 0.02
- sleep measurement · score 0.02
- neoplasm · score 0.02
- hemoglobin measurement · score 0.02
- cancer · score 0.01
- Ataxia-telangiectasia · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H1D9-F1 | alphafold | PREDICTED | 84.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H1D9.
Amino-acid sequence (316 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with POLR3F?
The strongest Open Targets associations for POLR3F are immunodeficiency 101 (varicella zoster virus-specific), neurofibrillary tangles measurement, body mass index, age at menarche and DNA methylation.
How long is the POLR3F protein?
The Homo sapiens POLR3F protein (UniProt Q9H1D9) is 316 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H1D9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H1D9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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