Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1)
Homo sapiens — UniProt Q9H1E3
Data last refreshed: (UniProt release unknown)
Key facts
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1) is a protein from Homo sapiens identified by UniProt accession Q9H1E3, 243 residues long. MolForge cross-references it against 0 known binders and 177 disease associations.
- UniProt accession: Q9H1E3; gene symbol NUCKS1.
- Organism: Homo sapiens.
- Length: 243 amino acids.
- Top disease associations (Open Targets): lean body mass, alkaline phosphatase measurement and appendicular lean mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 |
|---|---|
| UniProt accession | Q9H1E3 |
| Gene | NUCKS1 |
| Organism | Homo sapiens |
| Length | 243 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (177)
Diseases linked to this target (Open Targets).
- lean body mass · score 0.35
- alkaline phosphatase measurement · score 0.34
- appendicular lean mass · score 0.34
- Parkinson disease · score 0.34
- atrial fibrillation · score 0.33
- vital capacity · score 0.32
- body height · score 0.31
- alcohol consumption measurement · score 0.30
- sex hormone-binding globulin measurement · score 0.30
- high density lipoprotein cholesterol measurement · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H1E3-F1 | alphafold | PREDICTED | 58.13 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H1E3.
Amino-acid sequence (243 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NUCKS1?
The strongest Open Targets associations for NUCKS1 are lean body mass, alkaline phosphatase measurement, appendicular lean mass, Parkinson disease and atrial fibrillation.
How long is the NUCKS1 protein?
The Homo sapiens NUCKS1 protein (UniProt Q9H1E3) is 243 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H1E3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H1E3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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