Thioredoxin-related transmembrane protein 4 (TMX4)
Homo sapiens — UniProt Q9H1E5
Data last refreshed: (UniProt release unknown)
Key facts
Thioredoxin-related transmembrane protein 4 (TMX4) is a protein from Homo sapiens identified by UniProt accession Q9H1E5, 349 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.
- UniProt accession: Q9H1E5; gene symbol TMX4.
- Organism: Homo sapiens.
- Length: 349 amino acids.
- Top disease associations (Open Targets): triglyceride measurement, sleep duration and colorectal cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Thioredoxin-related transmembrane protein 4 |
|---|---|
| UniProt accession | Q9H1E5 |
| Gene | TMX4 |
| Organism | Homo sapiens |
| Length | 349 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (54)
Diseases linked to this target (Open Targets).
- triglyceride measurement · score 0.30
- sleep duration · score 0.30
- colorectal cancer · score 0.13
- heel bone mineral density · score 0.12
- bone quantitative ultrasound measurement · score 0.10
- ossification of the posterior longitudinal ligament of the spine · score 0.09
- dentures · score 0.08
- dental caries · score 0.08
- BMI-adjusted waist circumference · score 0.08
- colorectal adenoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H1E5-F1 | alphafold | PREDICTED | 72.36 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H1E5.
Amino-acid sequence (349 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMX4?
The strongest Open Targets associations for TMX4 are triglyceride measurement, sleep duration, colorectal cancer, heel bone mineral density and bone quantitative ultrasound measurement.
How long is the TMX4 protein?
The Homo sapiens TMX4 protein (UniProt Q9H1E5) is 349 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H1E5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H1E5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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