Activating signal cointegrator 1 complex subunit 2 (ASCC2)
Homo sapiens — UniProt Q9H1I8
Data last refreshed: (UniProt release unknown)
Key facts
Activating signal cointegrator 1 complex subunit 2 (ASCC2) is a protein from Homo sapiens identified by UniProt accession Q9H1I8, 757 residues long. MolForge cross-references it against 0 known binders and 76 disease associations.
- UniProt accession: Q9H1I8; gene symbol ASCC2.
- Organism: Homo sapiens.
- Length: 757 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, type 2 diabetes mellitus and hemoglobin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Activating signal cointegrator 1 complex subunit 2 |
|---|---|
| UniProt accession | Q9H1I8 |
| Gene | ASCC2 |
| Organism | Homo sapiens |
| Length | 757 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (76)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- type 2 diabetes mellitus · score 0.30
- hemoglobin measurement · score 0.28
- Immature Reticulocyte Fraction Measurement · score 0.21
- breast adenocarcinoma · score 0.18
- lymphocyte count · score 0.16
- FEV/FVC ratio · score 0.16
- pulse pressure measurement · score 0.16
- self reported educational attainment · score 0.15
- mean corpuscular hemoglobin concentration · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H1I8-F1 | alphafold | PREDICTED | 77.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H1I8.
Amino-acid sequence (757 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ASCC2?
The strongest Open Targets associations for ASCC2 are neurodegenerative disease, type 2 diabetes mellitus, hemoglobin measurement, Immature Reticulocyte Fraction Measurement and breast adenocarcinoma.
How long is the ASCC2 protein?
The Homo sapiens ASCC2 protein (UniProt Q9H1I8) is 757 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H1I8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H1I8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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