Regulator of nonsense transcripts 3A (UPF3A)
Homo sapiens — UniProt Q9H1J1
Data last refreshed: (UniProt release unknown)
Key facts
Regulator of nonsense transcripts 3A (UPF3A) is a protein from Homo sapiens identified by UniProt accession Q9H1J1, 476 residues long. MolForge cross-references it against 0 known binders and 103 disease associations.
- UniProt accession: Q9H1J1; gene symbol UPF3A.
- Organism: Homo sapiens.
- Length: 476 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, endometrial cancer and sex hormone-binding globulin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Regulator of nonsense transcripts 3A |
|---|---|
| UniProt accession | Q9H1J1 |
| Gene | UPF3A |
| Organism | Homo sapiens |
| Length | 476 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (103)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- endometrial cancer · score 0.23
- sex hormone-binding globulin measurement · score 0.19
- pulse pressure measurement · score 0.17
- body height · score 0.16
- appendicular lean mass · score 0.15
- forced expiratory volume · score 0.15
- eosinophil count · score 0.11
- eosinophil percentage of leukocytes · score 0.10
- systolic blood pressure · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H1J1-F1 | alphafold | PREDICTED | 62.14 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H1J1.
Amino-acid sequence (476 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with UPF3A?
The strongest Open Targets associations for UPF3A are neurodegenerative disease, endometrial cancer, sex hormone-binding globulin measurement, pulse pressure measurement and body height.
How long is the UPF3A protein?
The Homo sapiens UPF3A protein (UniProt Q9H1J1) is 476 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H1J1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H1J1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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