Protein Wnt-8a (WNT8A)
Homo sapiens — UniProt Q9H1J5
Data last refreshed: (UniProt release unknown)
Key facts
Protein Wnt-8a (WNT8A) is a protein from Homo sapiens identified by UniProt accession Q9H1J5, 351 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.
- UniProt accession: Q9H1J5; gene symbol WNT8A.
- Organism: Homo sapiens.
- Length: 351 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, type 2 diabetes mellitus and ovarian cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein Wnt-8a |
|---|---|
| UniProt accession | Q9H1J5 |
| Gene | WNT8A |
| Organism | Homo sapiens |
| Length | 351 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (40)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.43
- type 2 diabetes mellitus · score 0.19
- ovarian cancer · score 0.19
- endometrial cancer · score 0.18
- atrial fibrillation · score 0.18
- glioblastoma multiforme · score 0.17
- atrial flutter · score 0.16
- erythrocyte count · score 0.15
- hematocrit · score 0.15
- platelet count · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H1J5-F1 | alphafold | PREDICTED | 83.32 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H1J5.
Amino-acid sequence (351 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with WNT8A?
The strongest Open Targets associations for WNT8A are neurodegenerative disease, type 2 diabetes mellitus, ovarian cancer, endometrial cancer and atrial fibrillation.
How long is the WNT8A protein?
The Homo sapiens WNT8A protein (UniProt Q9H1J5) is 351 amino acids long.
Browse: Targets: W · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H1J5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H1J5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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