Iron-sulfur cluster assembly enzyme ISCU (ISCU)
Homo sapiens — UniProt Q9H1K1
Data last refreshed: (UniProt release unknown)
Key facts
Iron-sulfur cluster assembly enzyme ISCU (ISCU) is a protein from Homo sapiens identified by UniProt accession Q9H1K1, 167 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.
- UniProt accession: Q9H1K1; gene symbol ISCU.
- Organism: Homo sapiens.
- Length: 167 amino acids.
- Top disease associations (Open Targets): hereditary myopathy with lactic acidosis due to ISCU deficiency, COVID-19 and mitochondrial disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Iron-sulfur cluster assembly enzyme ISCU |
|---|---|
| UniProt accession | Q9H1K1 |
| Gene | ISCU |
| Organism | Homo sapiens |
| Length | 167 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (34)
Diseases linked to this target (Open Targets).
- hereditary myopathy with lactic acidosis due to ISCU deficiency · score 0.73
- COVID-19 · score 0.37
- mitochondrial disease · score 0.37
- genetic disorder · score 0.19
- myopathy · score 0.11
- refractive error measurement · score 0.09
- Abnormality of refraction · score 0.06
- blood phosphate measurement · score 0.04
- P-selectin glycoprotein ligand 1 measurement · score 0.03
- smoking status measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H1K1-F1 | alphafold | PREDICTED | 85.19 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H1K1.
Amino-acid sequence (167 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ISCU?
The strongest Open Targets associations for ISCU are hereditary myopathy with lactic acidosis due to ISCU deficiency, COVID-19, mitochondrial disease, genetic disorder and myopathy.
How long is the ISCU protein?
The Homo sapiens ISCU protein (UniProt Q9H1K1) is 167 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H1K1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H1K1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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