Mitochondrial glutamate carrier 2 (SLC25A18)
Homo sapiens — UniProt Q9H1K4
Data last refreshed: (UniProt release unknown)
Key facts
Mitochondrial glutamate carrier 2 (SLC25A18) is a protein from Homo sapiens identified by UniProt accession Q9H1K4, 315 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q9H1K4; gene symbol SLC25A18.
- Organism: Homo sapiens.
- Length: 315 amino acids.
- Top disease associations (Open Targets): cutaneous melanoma, squamous cell lung carcinoma and medulloblastoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mitochondrial glutamate carrier 2 |
|---|---|
| UniProt accession | Q9H1K4 |
| Gene | SLC25A18 |
| Organism | Homo sapiens |
| Length | 315 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- cutaneous melanoma · score 0.13
- squamous cell lung carcinoma · score 0.11
- medulloblastoma · score 0.04
- psoriasis · score 0.02
- large cell medulloblastoma · score 0.01
- atypical teratoid rhabdoid tumor · score 0.01
- rosacea · score 0.01
- hepatocellular carcinoma · score 0.01
- colorectal cancer · score 0.01
- Acute hepatic failure · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H1K4-F1 | alphafold | PREDICTED | 73.11 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H1K4.
Amino-acid sequence (315 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC25A18?
The strongest Open Targets associations for SLC25A18 are cutaneous melanoma, squamous cell lung carcinoma, medulloblastoma, psoriasis and large cell medulloblastoma.
How long is the SLC25A18 protein?
The Homo sapiens SLC25A18 protein (UniProt Q9H1K4) is 315 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H1K4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H1K4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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