Beta-defensin 129 (DEFB129)
Homo sapiens — UniProt Q9H1M3
Data last refreshed: (UniProt release unknown)
Key facts
Beta-defensin 129 (DEFB129) is a protein from Homo sapiens identified by UniProt accession Q9H1M3, 183 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.
- UniProt accession: Q9H1M3; gene symbol DEFB129.
- Organism: Homo sapiens.
- Length: 183 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, cutaneous melanoma and endometrial cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Beta-defensin 129 |
|---|---|
| UniProt accession | Q9H1M3 |
| Gene | DEFB129 |
| Organism | Homo sapiens |
| Length | 183 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (13)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.39
- cutaneous melanoma · score 0.23
- endometrial cancer · score 0.21
- gastric adenocarcinoma · score 0.14
- breast adenocarcinoma · score 0.10
- neoplasm · score 0.04
- ovarian neoplasm · score 0.01
- obstructive sleep apnea · score 0.00
- ovarian carcinoma · score 0.00
- peritoneum cancer · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H1M3-F1 | alphafold | PREDICTED | 60.10 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H1M3.
Amino-acid sequence (183 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DEFB129?
The strongest Open Targets associations for DEFB129 are neurodegenerative disease, cutaneous melanoma, endometrial cancer, gastric adenocarcinoma and breast adenocarcinoma.
How long is the DEFB129 protein?
The Homo sapiens DEFB129 protein (UniProt Q9H1M3) is 183 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H1M3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H1M3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.