Beta-defensin 127 (DEFB127)
Homo sapiens — UniProt Q9H1M4
Data last refreshed: (UniProt release unknown)
Key facts
Beta-defensin 127 (DEFB127) is a protein from Homo sapiens identified by UniProt accession Q9H1M4, 99 residues long. MolForge cross-references it against 0 known binders and 6 disease associations.
- UniProt accession: Q9H1M4; gene symbol DEFB127.
- Organism: Homo sapiens.
- Length: 99 amino acids.
- Top disease associations (Open Targets): cutaneous melanoma, endometrial cancer and squamous cell lung carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Beta-defensin 127 |
|---|---|
| UniProt accession | Q9H1M4 |
| Gene | DEFB127 |
| Organism | Homo sapiens |
| Length | 99 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (6)
Diseases linked to this target (Open Targets).
- cutaneous melanoma · score 0.23
- endometrial cancer · score 0.21
- squamous cell lung carcinoma · score 0.17
- breast adenocarcinoma · score 0.10
- Autosomal dominant striatal neurodegeneration · score 0.04
- AIDS · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H1M4-F1 | alphafold | PREDICTED | 81.73 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H1M4.
Amino-acid sequence (99 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DEFB127?
The strongest Open Targets associations for DEFB127 are cutaneous melanoma, endometrial cancer, squamous cell lung carcinoma, breast adenocarcinoma and Autosomal dominant striatal neurodegeneration.
How long is the DEFB127 protein?
The Homo sapiens DEFB127 protein (UniProt Q9H1M4) is 99 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H1M4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H1M4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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