Oxysterol-binding protein-related protein 2 (OSBPL2)
Homo sapiens — UniProt Q9H1P3
Data last refreshed: (UniProt release unknown)
Key facts
Oxysterol-binding protein-related protein 2 (OSBPL2) is a protein from Homo sapiens identified by UniProt accession Q9H1P3, 480 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.
- UniProt accession: Q9H1P3; gene symbol OSBPL2.
- Organism: Homo sapiens.
- Length: 480 amino acids.
- Top disease associations (Open Targets): autosomal dominant nonsyndromic hearing loss, deafness and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Oxysterol-binding protein-related protein 2 |
|---|---|
| UniProt accession | Q9H1P3 |
| Gene | OSBPL2 |
| Organism | Homo sapiens |
| Length | 480 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (69)
Diseases linked to this target (Open Targets).
- autosomal dominant nonsyndromic hearing loss · score 0.58
- deafness · score 0.51
- neurodegenerative disease · score 0.48
- lymphocyte count · score 0.21
- reticulocyte count · score 0.20
- Alzheimer disease · score 0.19
- Parkinson disease · score 0.19
- lysosomal storage disease · score 0.19
- multiple sclerosis · score 0.19
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H1P3-F1 | alphafold | PREDICTED | 83.17 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H1P3.
Amino-acid sequence (480 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with OSBPL2?
The strongest Open Targets associations for OSBPL2 are autosomal dominant nonsyndromic hearing loss, deafness, neurodegenerative disease, lymphocyte count and reticulocyte count.
How long is the OSBPL2 protein?
The Homo sapiens OSBPL2 protein (UniProt Q9H1P3) is 480 amino acids long.
Browse: Targets: O · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H1P3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H1P3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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