Multiple epidermal growth factor-like domains protein 9 (MEGF9)
Homo sapiens — UniProt Q9H1U4
Data last refreshed: (UniProt release unknown)
Key facts
Multiple epidermal growth factor-like domains protein 9 (MEGF9) is a protein from Homo sapiens identified by UniProt accession Q9H1U4, 602 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.
- UniProt accession: Q9H1U4; gene symbol MEGF9.
- Organism: Homo sapiens.
- Length: 602 amino acids.
- Top disease associations (Open Targets): reticulocyte count, body height and triglyceride measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Multiple epidermal growth factor-like domains protein 9 |
|---|---|
| UniProt accession | Q9H1U4 |
| Gene | MEGF9 |
| Organism | Homo sapiens |
| Length | 602 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (53)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.39
- body height · score 0.36
- triglyceride measurement · score 0.35
- self reported educational attainment · score 0.34
- reticulocyte measurement · score 0.31
- high density lipoprotein cholesterol measurement · score 0.28
- cortical thickness · score 0.28
- Immature Reticulocyte Fraction Measurement · score 0.27
- platelet count · score 0.27
- BMI-adjusted hip circumference · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H1U4-F1 | alphafold | PREDICTED | 66.47 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H1U4.
Amino-acid sequence (602 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MEGF9?
The strongest Open Targets associations for MEGF9 are reticulocyte count, body height, triglyceride measurement, self reported educational attainment and reticulocyte measurement.
How long is the MEGF9 protein?
The Homo sapiens MEGF9 protein (UniProt Q9H1U4) is 602 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H1U4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H1U4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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