Autophagy protein 5 (ATG5)
Homo sapiens — UniProt Q9H1Y0
Data last refreshed: (UniProt release unknown)
Key facts
Autophagy protein 5 (ATG5) is a protein from Homo sapiens identified by UniProt accession Q9H1Y0, 275 residues long. MolForge cross-references it against 0 known binders and 509 disease associations.
- UniProt accession: Q9H1Y0; gene symbol ATG5.
- Organism: Homo sapiens.
- Length: 275 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, eosinophil count and systemic lupus erythematosus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Autophagy protein 5 |
|---|---|
| UniProt accession | Q9H1Y0 |
| Gene | ATG5 |
| Organism | Homo sapiens |
| Length | 275 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (509)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.55
- eosinophil count · score 0.39
- systemic lupus erythematosus · score 0.34
- Intellectual disability-coarse face-macrocephaly-cerebellar hypotrophy syndrome · score 0.33
- total blood protein measurement · score 0.33
- rheumatoid arthritis · score 0.32
- systemic scleroderma · score 0.32
- eosinophil percentage of leukocytes · score 0.32
- childhood onset asthma · score 0.30
- lysosomal storage disease · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H1Y0-F1 | alphafold | PREDICTED | 93.24 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H1Y0.
Amino-acid sequence (275 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ATG5?
The strongest Open Targets associations for ATG5 are neurodegenerative disease, eosinophil count, systemic lupus erythematosus, Intellectual disability-coarse face-macrocephaly-cerebellar hypotrophy syndrome and total blood protein measurement.
How long is the ATG5 protein?
The Homo sapiens ATG5 protein (UniProt Q9H1Y0) is 275 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H1Y0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H1Y0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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