Mediator of RNA polymerase II transcription subunit 28 (MED28)
Homo sapiens — UniProt Q9H204
Data last refreshed: (UniProt release unknown)
Key facts
Mediator of RNA polymerase II transcription subunit 28 (MED28) is a protein from Homo sapiens identified by UniProt accession Q9H204, 178 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.
- UniProt accession: Q9H204; gene symbol MED28.
- Organism: Homo sapiens.
- Length: 178 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, platelet count and hereditary breast ovarian cancer syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mediator of RNA polymerase II transcription subunit 28 |
|---|---|
| UniProt accession | Q9H204 |
| Gene | MED28 |
| Organism | Homo sapiens |
| Length | 178 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (48)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- platelet count · score 0.16
- hereditary breast ovarian cancer syndrome · score 0.12
- Hereditary breast and ovarian cancer syndrome · score 0.12
- platelet crit · score 0.12
- breast adenocarcinoma · score 0.11
- cortical thickness · score 0.08
- mathematical ability · score 0.06
- self reported educational attainment · score 0.05
- bone quantitative ultrasound measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H204-F1 | alphafold | PREDICTED | 78.88 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H204.
Amino-acid sequence (178 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MED28?
The strongest Open Targets associations for MED28 are neurodegenerative disease, platelet count, hereditary breast ovarian cancer syndrome, Hereditary breast and ovarian cancer syndrome and platelet crit.
How long is the MED28 protein?
The Homo sapiens MED28 protein (UniProt Q9H204) is 178 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H204 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H204 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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