About DNA replication factor Cdt1
DNA replication factor Cdt1 (CDT1) is a protein
from Homo sapiens identified by UniProt accession
Q9H211, 546 residues long.
MolForge cross-references it against 0 known binders and
124 disease associations.
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
Disease associations (124)
Diseases linked to this target (Open Targets).
- Ear-patella-short stature syndrome · score 0.81
- neurodegenerative disease · score 0.45
- microcephalic primordial dwarfism · score 0.37
- Meier-Gorlin syndrome · score 0.27
- hemoglobin measurement · score 0.26
- glioblastoma multiforme · score 0.25
- genetic disorder · score 0.19
- Red cell distribution width · score 0.19
- mean corpuscular volume · score 0.17
- mean corpuscular hemoglobin concentration · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
Experimental structures are not indexed in MolForge yet —
search RCSB PDB for Q9H211.
Amino-acid sequence (546 residues)
MEQRRVTDFF ARRRPGPPRI APPKLACRTP SPARPALRAP ASATSGSRKR ARPPAAPGRD QARPPARRRL RLSVDEVSSP STPEAPDIPA CPSPGQKIKK STPAAGQPPH LTSAQDQDTI SELASCLQRA RELGARVRAL KASAQDAGES CTPEAEGRPE EPCGEKAPAY QRFHALAQPG LPGLVLPYKY QVLAEMFRSM DTIVGMLHNR SETPTFAKVQ RGVQDMMRRR FEECNVGQIK TVYPASYRFR QERSVPTFKD GTRRSDYQLT IEPLLEQEAD GAAPQLTASR LLQRRQIFSQ KLVEHVKEHH KAFLASLSPA MVVPEDQLTR WHPRFNVDEV PDIEPAALPQ PPATEKLTTA QEVLARARNL ISPRMEKALS QLALRSAAPS SPGSPRPALP ATPPATPPAA SPSALKGVSQ DLLERIRAKE AQKQLAQMTR CPEQEQRLQR LERLPELARV LRSVFVSERK PALSMEVACA RMVGSCCTIM SPGEMEKHLL LLSELLPDWL SLHRIRTDTY VKLDKAADLA HITARLAHQT RAEEGL
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