ATP-binding cassette sub-family G member 8 (ABCG8)
Homo sapiens — UniProt Q9H221
Data last refreshed: (UniProt release unknown)
Key facts
ATP-binding cassette sub-family G member 8 (ABCG8) is a protein from Homo sapiens identified by UniProt accession Q9H221, 673 residues long. MolForge cross-references it against 0 known binders and 266 disease associations.
- UniProt accession: Q9H221; gene symbol ABCG8.
- Organism: Homo sapiens.
- Length: 673 amino acids.
- Top disease associations (Open Targets): sitosterolemia, cholelithiasis and Abnormality of the cardiovascular system.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ATP-binding cassette sub-family G member 8 |
|---|---|
| UniProt accession | Q9H221 |
| Gene | ABCG8 |
| Organism | Homo sapiens |
| Length | 673 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (266)
Diseases linked to this target (Open Targets).
- sitosterolemia · score 0.75
- cholelithiasis · score 0.64
- Abnormality of the cardiovascular system · score 0.53
- Disorder of lipid metabolism · score 0.52
- familial hypercholesterolemia · score 0.52
- low density lipoprotein cholesterol measurement · score 0.51
- total cholesterol measurement · score 0.49
- Hypercholesterolemia · score 0.48
- gallstones · score 0.40
- Abnormal circulating lipid concentration · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H221-F1 | alphafold | PREDICTED | 80.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H221.
Amino-acid sequence (673 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ABCG8?
The strongest Open Targets associations for ABCG8 are sitosterolemia, cholelithiasis, Abnormality of the cardiovascular system, Disorder of lipid metabolism and familial hypercholesterolemia.
How long is the ABCG8 protein?
The Homo sapiens ABCG8 protein (UniProt Q9H221) is 673 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H221 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H221 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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