ATP-binding cassette sub-family G member 5 (ABCG5)
Homo sapiens — UniProt Q9H222
Data last refreshed: (UniProt release unknown)
Key facts
ATP-binding cassette sub-family G member 5 (ABCG5) is a protein from Homo sapiens identified by UniProt accession Q9H222, 651 residues long. MolForge cross-references it against 0 known binders and 303 disease associations.
- UniProt accession: Q9H222; gene symbol ABCG5.
- Organism: Homo sapiens.
- Length: 651 amino acids.
- Top disease associations (Open Targets): sitosterolemia, cholelithiasis and low density lipoprotein cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ATP-binding cassette sub-family G member 5 |
|---|---|
| UniProt accession | Q9H222 |
| Gene | ABCG5 |
| Organism | Homo sapiens |
| Length | 651 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (303)
Diseases linked to this target (Open Targets).
- sitosterolemia · score 0.75
- cholelithiasis · score 0.66
- low density lipoprotein cholesterol measurement · score 0.62
- total cholesterol measurement · score 0.61
- apolipoprotein B measurement · score 0.55
- Abnormality of the cardiovascular system · score 0.54
- familial hypercholesterolemia · score 0.51
- Disorder of lipid metabolism · score 0.51
- Hypercholesterolemia · score 0.46
- atherosclerosis · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H222-F1 | alphafold | PREDICTED | 85.04 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H222.
Amino-acid sequence (651 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ABCG5?
The strongest Open Targets associations for ABCG5 are sitosterolemia, cholelithiasis, low density lipoprotein cholesterol measurement, total cholesterol measurement and apolipoprotein B measurement.
How long is the ABCG5 protein?
The Homo sapiens ABCG5 protein (UniProt Q9H222) is 651 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H222 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H222 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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