EH domain-containing protein 4 (EHD4)
Homo sapiens — UniProt Q9H223
Data last refreshed: (UniProt release unknown)
Key facts
EH domain-containing protein 4 (EHD4) is a protein from Homo sapiens identified by UniProt accession Q9H223, 541 residues long. MolForge cross-references it against 0 known binders and 134 disease associations.
- UniProt accession: Q9H223; gene symbol EHD4.
- Organism: Homo sapiens.
- Length: 541 amino acids.
- Top disease associations (Open Targets): monocyte count, leukocyte count and neutrophil count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | EH domain-containing protein 4 |
|---|---|
| UniProt accession | Q9H223 |
| Gene | EHD4 |
| Organism | Homo sapiens |
| Length | 541 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (134)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.43
- leukocyte count · score 0.43
- neutrophil count · score 0.42
- lymphocyte percentage of leukocytes · score 0.40
- myeloid white cell count · score 0.39
- mean platelet volume · score 0.38
- reticulocyte measurement · score 0.36
- neutrophil percentage of leukocytes · score 0.36
- platelet count · score 0.36
- eosinophil count · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H223-F1 | alphafold | PREDICTED | 87.74 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H223.
Amino-acid sequence (541 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EHD4?
The strongest Open Targets associations for EHD4 are monocyte count, leukocyte count, neutrophil count, lymphocyte percentage of leukocytes and myeloid white cell count.
How long is the EHD4 protein?
The Homo sapiens EHD4 protein (UniProt Q9H223) is 541 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H223 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H223 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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